Wednesday, July 05, 2006
Smurf blood!
******Rez/Cowgirl By Underworld******I want my youth Back!!!!

Name: Novantrone, mitoxantrone
Marketed By: Immunex Corporation/Serono Incorporated
Intended Use: For the treatment of secondary-progressive MS, progressive-relapsing MS, worsening relapsing-remitting MS, and certain forms of cancer such as acute myelogenous leukemia and honnone-refractory prostate cancer.

Profile of User: An individual with a definite diagnosis of secondary-progressive MS, progressive-relapsing MS, worsening relapsing-remitting MS, and certain forms of cancer and who does not have heart disease.

What It Is: A synthetic form of anthracenedione, which is an antineoplatic drug (a substance that blocks the formation of growths that may become cancerous) that belongs to the family of drugs called anticancer antibiotics. It is a type of chemotherapy

How It Works: Novantrone is an immuno-suppressant that kills T-cells, B-cells, and macrophages (cells in the immune system). When a person develops MS, these cells are thought to become abnormal and attack the myelin sheath.

History:
- Trials of Novantrone for the treatment of progressive forms of MS occurred over a ten year period, involving multi-centre, double-blind trials in different parts of Europe.
- As a result of those trials, the U.S. FDA approved Novantrone for the treatment of secondary-progressive MS, progressive-relapsing MS, and worsening relapsing-remitting MS in 2000.
- In 2005, the FDA added a boxed warning to Novantrone about the potential risk of heart damage and a form of leukemia called secondary acute myelogenous leukemia.
- Novantrone is not yet approved in Canada for the treatment of MS, but is still prescribed by doctors for MS (off-label use).
Benefits: Novantrone delays the time to first treated relapse and disability progression. It also reduces relapses and the number of new lesions detected by MRI scans.

Administration: Four times a year by IV infusion in a medical facility. Lifetime limit of 8-12 doses (12 mg/m2 every 3 months).
Cost: The wholesale cost of Novantrone is between $1400-$2300 USD (depending on dose amount) for each use, and is used 3 or 4 times a year for two years. The cost in Canada is approximately half of that. Coverage varies.

And now the bad bits:
Side Effects/Disadvantages:
- Blue-green urine 24 hours after administration(not exactly a barrel of laughs!)
- Infections
- Bone marrow suppression (fatigue, bruising, low blood cell counts)
- Nausea
- Diarrhea
- Hair thinning(WHAT!!!!!!!)
- Bladder infections
- Mouth sores
- Serious heart and liver problems
- In very rare cases, secondary acute myelogenous leukemia

****Wow, I know this one worked for me, even with the blue urine, I would say its the best feel good factor after the nausea runs out! It can take a while to kick in but when its working you will feel it! I had a full day in hospital with it on a drip!

Any way I will go back to diary soon. I havent seen Jen for a week and wont till next tuesday. God I need some music here soon!

Hope you are all being good and your all well!
Dave
posted by personallog! @ 10:23 am  
2 Comments:
  • At 11:18 am, Anonymous Anonymous said…

    thank you for that very straight forward info on mitox

    my name is lauren im 23 and hopefully going ahead with this treatment soon. just waiting on a echo crdio gram but i have had my MRI.My MS t date has been very agressive with relapses at least every 6 months (5 weeks at the mo) since May 03

    well thats a quick hello for now

    i like your site and will be back

    Lauren x

     
  • At 11:27 am, Blogger personallog! said…

    The 1st day after the treatment is the worst, you doc can give you tablets for the sickness so dont worry about it to much, you will grow to love it honestly. Good luck Lauren I wish you well.

    Dave

     
Post a comment
<< Home
 
ms....not just a diary
About Me

Name: personallog!
Home: St. Annes, Lancashire, United Kingdom
About Me:
I am 6ft 3" skinny and not well. I was diagnosed with ms in 2004 and I would like to speak with others who have ms. I have a want to raise money for ms charities. We have to find a cure for this hell!!!! See my complete profile

More of ME
ms/disabilty reads
Family
Other Interests
Previous Post
Archives